CVS – HISTO

CVS

CVS – HISTOLOGY

Compiled Topical Questions of CVS – Histo

“Please enter your name and email so that we maybe able to send you statistics, but more importantly, a nice certificate upon completion. Thank you for using MedifyHelp!”

Focus on the specialized junctions that connect cardiac muscle cells end-to-end, allowing synchronized contraction of the heart.

1 / 54

Tags: 2024

A medical student in the exam of his 1st professional year identified a slide under the microscope as cardiac muscle. The point he must have considered to identify the slide is that it/its?

Cells have multiple nuclei

Nuclei are peripherally arranged

Has diads

Fibers are non-striated

Has intercalated discs

Think about the thin, smooth layer that allows blood to flow without friction and lines both the heart chambers and blood vessels.

2 / 54

Tags: 2024

The inner lining of the heart chambers is continuous with the inner layer of blood vessels. Its epithelium is?

Simple squamous

Simple columnar

Pseudostratified ciliated columnar

Simple squamous

Stratified cuboidal

Consider the type of fibers that allow large arteries to stretch during systole and recoil during diastole, helping to maintain continuous blood flow.

3 / 54

Tags: 2024

The aorta and pulmonary trunk are classified as large arteries arising from the heart. The fibers found in abundance in these vessels are?

Muscular fibers

Connective tissue type 1 fibers

Elastic fibers

Connective tissue type 2 fibers

Reticular fibers

The lymphatic system is responsible for draining excess fluid from most tissues. However, some regions lack lymphatic vessels because their function does not require lymphatic drainage. Which areas rely on blood circulation instead of lymphatic drainage?

4 / 54

Tags: 2020

Pick the odd one out regarding lymphatic capillaries.

Remove excess fluid from interstitial space

Begin as blind ended tubes

Present in bone marrow

Have a single layer of endothelium

Have discontinuous basal lamina

Lymphatic capillaries are specialized thin-walled vessels that collect excess interstitial fluid, proteins, and immune cells and transport them back into the venous circulation. They have unique structural adaptations that allow for efficient drainage of interstitial fluid.

Key Features of Lymphatic Capillaries:

1️⃣ Have a discontinuous basal lamina

Unlike blood capillaries, lymphatic capillaries have an incomplete or absent basement membrane, allowing easy fluid entry.

2️⃣ Have a single layer of endothelium

Their walls consist of a single layer of endothelial cells, which overlap like flaps to permit the entry of interstitial fluid.

3️⃣ Begin as blind-ended tubes

Unlike blood capillaries, lymphatic capillaries do not form continuous loops; they start as closed-end tubes, making them ideal for fluid absorption.

4️⃣ Remove excess fluid from interstitial space

One of their primary functions is to prevent tissue edema by returning excess fluid to the bloodstream.

Why “Present in bone marrow” is the odd one out?

🔹 Lymphatic capillaries are absent in the bone marrow.
✔️ Bone marrow lacks lymphatic capillaries because immune cells (e.g., lymphocytes) are released into the blood circulation, not the lymphatic system.
✔️ The lymphatic system is found in most tissues, but it is absent in bone marrow, brain, and avascular tissues like cartilage and the cornea.

Analysis of Each Option:

✅ Correct Answer (Odd One Out):
🔹 “Present in bone marrow”
✔️ Lymphatic capillaries are not present in bone marrow.

🚫 Correct Statements (Incorrect Choices):

🔹 “Have discontinuous basal lamina”
✔️ True – This allows for the easy movement of fluid and immune cells into lymphatic vessels.

🔹 “Have a single layer of endothelium”
✔️ True – Lymphatic capillaries are lined by a single layer of endothelial cells without tight junctions, making them highly permeable.

🔹 “Begin as blind-ended tubes”
✔️ True – Lymphatic capillaries do not form a continuous circuit like blood capillaries; they begin as closed-ended tubes in tissues.

🔹 “Remove excess fluid from interstitial space”
✔️ True – This is the primary function of lymphatic capillaries, helping to prevent edema and maintain fluid balance.

The ventricles require what kind of structure to handle high pressure and forceful contractions. Which part of the heart does the most mechanical work, and how would this affect the work?

5 / 54

Tags: 2020

The endocardium is the innermost layer of the heart. What is inappropriate regarding this layer?

Endocardium continues with the inner layer of the great vessels emerging from the heart

Endocardium is the thickest in atria

Endocardium has a deeper layer of connective tissue

Endocardium is much thicker in ventricles

Endocardium has a supporting layer of fibroelastic connective tissue

The endocardium is the innermost layer of the heart, lining the chambers and covering the heart valves. It plays a crucial role in maintaining smooth blood flow, preventing clot formation, and regulating myocardial function.

The thickness of the endocardium varies across different chambers of the heart, but it is generally thicker in the ventricles than in the atria.

Key Features of the Endocardium:

Composition:
- Endothelium (simple squamous epithelium)
- Subendothelial fibroelastic connective tissue
- Deeper layer with Purkinje fibers and blood vessels
Regional Thickness:
- Thicker in the ventricles, especially in the left ventricle, due to higher pressures.
- Thinner in the atria, as atrial contraction does not require as much force.

Thus, the statement “Endocardium is the thickest in atria” is incorrect, making it the best answer choice.

Analysis of Each Option:

✅ Incorrect Statement (Correct Answer):
🔹 “Endocardium is the thickest in atria.”
❌ The endocardium is actually thicker in the ventricles, especially in the left ventricle, due to the high-pressure environment.
❌ The atria have a thinner endocardium as they operate under lower pressure.

🚫 Correct Statements (Incorrect Choices):

🔹 “Endocardium is much thicker in ventricles.”
✔️ True – The ventricles, particularly the left ventricle, have a thicker endocardium due to the high-pressure workload.

🔹 “Endocardium has a deeper layer of connective tissue.”
✔️ True – The deep layer contains fibroelastic connective tissue, capillaries, and in the ventricles, Purkinje fibers, which are important for conduction.

🔹 “Endocardium continues with the inner layer of the great vessels emerging from the heart.”
✔️ True – The endocardium is continuous with the tunica intima of the aorta, pulmonary artery, superior vena cava, and inferior vena cava.

🔹 “Endocardium has a supporting layer of fibroelastic connective tissue.”
✔️ True – The subendothelial layer consists of fibroelastic connective tissue, providing structural support and elasticity.

Blood vessels must adapt to different pressures and functions. Think about which vessel experiences the highest pressure fluctuations and must stretch and recoil to accommodate the forceful ejection of blood from the heart.

6 / 54

Tags: 2020

During a tutorial class, the microscopic structure of the tunica media was being discussed. It was concluded that it consists of concentric layers of smooth muscle with variable amounts of elastic and reticular fibers in between. Which of the following vessels contains the largest amount of elastic fibers in its tunica media?

Medium sized artery

Aorta

Jugular vein

Inferior vena cava

Coronary artery

The tunica media is the middle layer of a blood vessel wall and plays a crucial role in maintaining vascular tone and elasticity. It primarily consists of smooth muscle cells, elastic fibers, and reticular fibers arranged in concentric layers. The proportion of these components varies depending on the type of blood vessel.

The aorta, being the largest elastic artery, contains the highest amount of elastic fibers in its tunica media. These elastic fibers form lamellae (elastic sheets), allowing the aorta to stretch and recoil with each cardiac cycle. This property is essential for dampening the pulsatile force of blood ejected from the left ventricle, ensuring smooth and continuous blood flow throughout the body.

Analysis of Each Option:

✅ Correct Option:
🔹 “Aorta”
✔️ The aorta is a large elastic artery that experiences the highest pressure from cardiac output. To withstand this pressure, its tunica media is rich in elastic fibers arranged in lamellar layers, allowing it to expand during systole and recoil during diastole. This elastic recoil helps maintain diastolic blood pressure and continuous perfusion of distal tissues.

🚫 Incorrect Options:

🔹 “Coronary artery”
❌ The coronary arteries are muscular arteries, not elastic arteries. While they do contain some elastic fibers, they primarily have more smooth muscle in the tunica media, allowing them to regulate blood flow by vasoconstriction and vasodilation.

🔹 “Jugular vein”
❌ Veins generally have a much thinner tunica media compared to arteries because they operate under low pressure. The jugular vein, like most veins, contains few elastic fibers and relies on valves and surrounding skeletal muscles to aid in blood return to the heart.

🔹 “Medium-sized artery”
❌ Medium-sized arteries, also called muscular arteries, include the radial, brachial, and femoral arteries. They have a well-developed tunica media, but it is primarily composed of smooth muscle rather than elastic fibers. These arteries are designed for vasoregulation, not elasticity.

🔹 “Inferior vena cava”
❌ The inferior vena cava (IVC) is a large vein, but veins in general have less elastic fibers compared to arteries. The IVC has a thin tunica media with more collagen and fewer elastic fibers, making it highly distensible but not elastic like the aorta.

The cardiac myocyte has a unique appearance under the microscope — it’s striated like skeletal muscle but also shares features with smooth muscle. Think about what feature distinguishes cardiac cells when you look for their nucleus position and overall shape.

7 / 54

Tags: 2017

A histopathologist is examining the slide of a heart muscle under microscope. Which of the following is the correct feature of cardiac myocyte?

Spindle shaped muscle fibres

Single centrally located nucleus

Sarcomere in triads with T tubule

Nuclei arranged at the periphery of the cell

Multinucleated cell

Cardiac myocytes (cardiac muscle cells) have a distinct appearance and several key features that differentiate them from skeletal and smooth muscle cells:

Single, centrally located nucleus:
- Cardiac myocytes typically have one nucleus, but some may have two.
- The nucleus is centrally placed within the cell, a key identifying feature.
- Skeletal muscle, by contrast, has multiple peripheral nuclei.
Striated appearance:
- Cardiac muscle contains sarcomeres, the same contractile units found in skeletal muscle, giving it visible striations under the microscope.
Intercalated discs:
- Unique to cardiac muscle, these specialized junctional complexes connect adjacent myocytes, allowing for synchronized contraction.
- They contain gap junctions, desmosomes, and adherens junctions.
Branched fibers:
- Cardiac muscle cells are short, branched, and connected end-to-end — unlike the long, cylindrical fibers of skeletal muscle.
Dyads, not triads:
- Cardiac myocytes have dyads: one T-tubule and one terminal cisterna of the sarcoplasmic reticulum at the Z-line.
- Skeletal muscle has triads (one T-tubule with two terminal cisternae) at the A-I junction.

Why the other options are incorrect:

Multinucleated cell:
- Seen in skeletal muscle, where cells are long and cylindrical with many nuclei along the periphery.
- Cardiac myocytes usually have one (sometimes two) nuclei, and they are central, not multiple.
Nuclei arranged at the periphery of the cell:
- A feature of skeletal muscle, not cardiac muscle.
Spindle-shaped muscle fibers:
- Describes smooth muscle, which has no striations and is found in the walls of hollow organs (e.g., blood vessels, intestines).
- Cardiac myocytes are branched and striated, not spindle-shaped.
Sarcomere in triads with T tubule:
- Seen in skeletal muscle, where triads (1 T-tubule + 2 terminal cisternae) are found at the A-I junction.
- Cardiac muscle has dyads at the Z-line.

Conclusion:
Cardiac myocytes are easily recognized by their single centrally located nucleus, striations, branched fibers, and intercalated discs. Understanding these features helps distinguish them from skeletal and smooth muscle under the microscope.

“Which type of artery is responsible for distributing blood to different organs and needs a well-defined structure to regulate blood flow efficiently?”

8 / 54

Tags: 2019

Which of the following types of vessels has a smooth muscle layer in between two elastic laminae?

Arteriole

Muscular artery

Medium-sized vein

Lymphatic vessels

Elastic artery

“These arteries are known for their ability to regulate blood flow and pressure through vasoconstriction and vasodilation.”

9 / 54

Tags: 2019

What is true regarding muscular arteries?

Concentric elastic in the media

Vasa vasorum in the intima

None of these

Muscular adventitia

Concentric layer of smooth muscles in the media

“These capillaries have no pores, yet they need a way to transport nutrients and waste across their walls. How do they compensate for the lack of openings?”

10 / 54

Tags: 2022

In which of the blood vessels are pinocytotic vesicles seen?

Continuous capillaries

Discontinuous capillaries

Fenestrated capillaries

Sinusoids

Aorta

The tunica media of the aorta must withstand high pressure and pulsatile blood flow. Which structural component provides the necessary thing to allow the aorta to stretch during systole and recoil during diastole, maintaining continuous blood flow?

11 / 54

Tags: 2022

What is the most abundant component of tunica media of the aorta?

Cholestrol

Reticular fibers

Smooth muscles

Elastin

Collagen

“This structural feature belongs to much smaller vessels that don’t have the same high-pressure demands as large arteries. Which option seems out of place?”

12 / 54

Tags: 2020

Which of these is odd about the structure of an elastic artery?

Presence of pericytes in tunica media

Presence of an internal elastic lamina

Presence of tunica intima

Presence of connective tissue

Presence of fenestrated elastic membrane in tunica media

“These structures aren’t equally distributed across all veins. Sometimes, general rules have exceptions.”

13 / 54

Tags: 2020

Which of these is inappropriate about valves in veins?

Prevent backflow of blood due to gravity

Made up of fibroelastic tissue with endothelium on both sides

They are present in veins having diameter greater than 0.5 mm

Not present in visceral veins

Protrusions of tunica intima of the vessels into the lumen

Why Option 1 (It is much thinner compared to that of an equivalent-sized artery) is Correct:

Veins, including medium veins, have a thinner tunica media than arteries of the same size. This is because veins have lower blood pressure and do not need the thick, muscular walls that arteries require to withstand the high pressure generated by the heart.

The tunica media in veins has a smaller amount of smooth muscle and elastic tissue compared to arteries, which allows veins to have a larger lumen and more compliant walls, facilitating their role in blood storage and return to the heart.

14 / 54

Tags: 2018

Which of the following is true regarding the tunica media of medium veins?

It is supported by a narrow band of supporting fibrous tissue

It is much thicker compared to that of an equivalent-sized artery

It consists mostly of smooth muscle fibers that run in a longitudinal directio

It consists mostly of circularly arranged collagen fibe

It is much thinner compared to that of an equivalent-sized artery

“This outermost layer of the heart also serves as a protective layer and houses structures like nerves, vessels, and fat.”

15 / 54

Tags: 2019

Which of the following layers of the heart contains nerves?

Sub-epithelial connective tissue

Epicardium

Myocardium

Epithelial layer

Sub-endothelial layer

Think about the functional differences between the largest arteries and medium-sized arteries. What structural features distinguish them, and what are they called?

16 / 54

Tags: 2020

Which of the following is inappropriate regarding the structure of vessels?

The largest arteries are also called distributing arteries

External elastic lamina is seen in the large muscular arteries

Tunica adventitia is thick in muscular arteries

Elastic layers with pores found in tunica media

Muscle is found between elastic lamina

Think about the structural adaptations that allow capillaries to perform their function of exchange. What feature would increase permeability in certain tissues?

17 / 54

Tags: 2020

Somatic and fenestrated capillaries are differentiated via what property?

Size of lumens

Number of cells in tunica intima

Presence/absence of endothelium

Presence/absence of pores or fenestrations in wall

Thickness of tunica intima

Think about the structural relationship between pericytes and blood vessels. What is essential for their integration and function within the vessel wall?

18 / 54

Tags: 2020

Pericytes are cells with muscular content. Which of the following is incorrect regarding pericytes?

Are contractile cells

Help in regulating blood flow

Found around capillaries and vessel

Present adjacent to capillaries

They do not share a common basement membrane to vessels

Think about how electrical impulses spread rapidly across the heart. What structures connect cardiac muscle cells to allow this coordinated activity?

19 / 54

Tags: 2020

Cardiac muscles act as syncytium due to which of the following reasons?

Intercalated discs

One nucleus per myocyte

Presence of many mitochondria

No myosin

Muscle fibres

Think about the function of the endocardium and the type of epithelium that would best facilitate smooth blood flow. What is the thinnest and least obstructive type of epithelium?

20 / 54

Tags: 2020

The endocardium has which of the following type of epithelium?

Simple columnar

Simple squamous

Specialized epithelium

Simple cuboidal

Stratified squamous non-keratinized

Think about the layers of the heart and their functions. What tissue lies beneath the endothelium to provide support and integration with the heart’s structure?

21 / 54

Tags: 2020

The endocardium consists of endothelium and what other tissue?

Nervous tissue

Fibrous tissue

Muscular tissue

Only endothelium

Thin connective tissue

Think about how electrical impulses spread rapidly across the heart. What structures in cardiac muscle cells ensure synchronized contraction?

22 / 54

Tags: 2020

What is the purpose of intercalated discs in the heart?

Tetany

Fatigue

Strong attachment between cells

Free flow of ions

Summation

The purpose of intercalated discs in the heart is to ensure the free flow of ions. Here’s why:

What are intercalated discs?
- Intercalated discs are specialized structures found at the junctions between cardiac muscle cells (cardiomyocytes).
- They are composed of three main components:
  - Gap junctions: These allow for the rapid passage of ions and electrical impulses between cells, enabling synchronized contraction.
  - Desmosomes: Provide strong mechanical adhesion between cells, preventing them from pulling apart during contraction.
  - Fascia adherens: Anchor actin filaments of the sarcomeres to the cell membrane, facilitating force transmission.
Why is the free flow of ions important?
- The heart functions as a functional syncytium, meaning it contracts as a single unit. This is essential for efficient pumping of blood.
- Gap junctions in intercalated discs allow ions (e.g., sodium, potassium, calcium) to flow freely between cells, ensuring rapid and coordinated spread of electrical impulses (action potentials) across the myocardium.
Why this is the primary purpose:
- While intercalated discs also provide strong mechanical attachment (via desmosomes and fascia adherens), their most critical function is facilitating electrical coupling through gap junctions. This ensures synchronized contraction of the heart.

Analysis of the Incorrect Options

Summation
Summation refers to the additive effect of multiple stimuli in muscle contraction. This is not related to the function of intercalated discs.
Strong attachment between cells
While intercalated discs do provide strong mechanical attachment through desmosomes and fascia adherens, this is not their primary purpose. The main function is electrical coupling via gap junctions.
Tetany
Tetany is a condition of sustained muscle contraction due to rapid repeated stimulation. It is not related to the function of intercalated discs.
Fatigue
Fatigue refers to the reduced ability of a muscle to generate force after prolonged activity. Intercalated discs do not play a role in preventing or causing fatigue.

“Cardiac muscle works tirelessly like skeletal muscle but communicates and contracts like no other. If it were structurally similar to smooth muscle, could it generate rapid, rhythmic contractions?”

23 / 54

Tags: 2018

Which of the following is the odd statement regarding the myocardium?

Cardiac muscles have high metabolic demands

MuscIe fibres are joined by intercalated discs

Cardiac myocytes have same contractile protein arrangement as smooth muscle

Certain location of cardiac cells secrete hormones

Cardiac muscle fibres form interconnecting network

The myocardium (heart muscle) is composed of cardiac muscle tissue, which has distinct structural and functional features that differ from both skeletal muscle and smooth muscle. One key difference is that cardiac muscle has a striated arrangement of contractile proteins, similar to skeletal muscle, but not to smooth muscle.

Cardiac and skeletal muscles share a sarcomeric organization, meaning actin and myosin filaments are arranged in a highly ordered, repeating pattern known as sarcomeres. This gives cardiac muscle its striated appearance under a microscope.
Smooth muscle, on the other hand, lacks sarcomeres and instead has a more random arrangement of actin and myosin filaments, which allows for slow, sustained contractions rather than rapid, forceful contractions like in the heart.

Since cardiac muscle does not share the same contractile arrangement as smooth muscle, this statement is incorrect and stands out as the odd one in the list.

Why the Other Options Are Correct:

✅ “Cardiac muscles have high metabolic demands.”

True. The myocardium has an extremely high metabolic demand because the heart must continuously contract without fatigue.
It relies primarily on aerobic metabolism, using fatty acids (60-80%) and glucose (20-40%) as energy sources.
Rich in mitochondria (about 30% of the cell volume), which supports continuous ATP production.

✅ “Certain locations of cardiac cells secrete hormones.”

True. Specialized atrial myocytes (mainly in the right atrium) secrete Atrial Natriuretic Peptide (ANP) in response to atrial stretching due to high blood pressure or volume overload.
Brain Natriuretic Peptide (BNP) is secreted by the ventricular myocytes under similar conditions.
These hormones promote vasodilation, natriuresis (sodium excretion), and diuresis (water loss), reducing blood volume and pressure.

✅ “Muscle fibers are joined by intercalated discs.”

True. Intercalated discs are unique junctions in cardiac muscle that contain:
- Desmosomes: Provide mechanical strength, preventing muscle fibers from pulling apart during contraction.
- Gap junctions: Allow for electrical coupling, enabling rapid action potential propagation and coordinated contraction.

✅ “Cardiac muscle fibers form an interconnecting network.”

True. Cardiac muscle fibers are arranged in a branched, interconnected network, unlike skeletal muscle, which has long, parallel fibers.
This interconnected structure allows for functional syncytium, meaning the entire myocardium contracts as a single unit.

“This major vessel originates from the heart and must withstand high pressure as it distributes oxygenated blood to the body. Its structure is designed to absorb and regulate the force of each heartbeat.”

24 / 54

Tags: 2020

The aorta is a big vessel arising from the heart. Which of the following is correct regarding the aorta?

Large sized artery

Arteriole

Large sized vein

Medium muscular artery

Small artery

The aorta is the largest artery in the body and originates from the left ventricle of the heart, distributing oxygenated blood to the systemic circulation.

Key Features of the Aorta:

Classification as a Large Artery (Elastic Artery):
- The aorta is a large, elastic artery that contains a high proportion of elastic fibers in its tunica media.
- This elasticity allows it to withstand high-pressure blood flow and maintain continuous blood circulation between heartbeats.
Function in the Cardiovascular System:
- The aorta receives blood directly from the left ventricle under high pressure.
- It expands during systole (when the heart contracts) and recoils during diastole (when the heart relaxes), helping to smooth out pulsatile blood flow.
Divisions of the Aorta:
- Ascending aorta → Arises from the left ventricle and gives rise to the coronary arteries.
- Aortic arch → Gives off the brachiocephalic trunk, left common carotid artery, and left subclavian artery.
- Descending thoracic aorta → Travels down the thorax, supplying the intercostal arteries.
- Abdominal aorta → Bifurcates into the common iliac arteries to supply the lower body.

Why the Correct Answer is Right:

✔ Large sized artery – Correct. The aorta is a large elastic artery, responsible for handling high-pressure blood flow and maintaining circulatory continuity.

Why the Other Options Are Incorrect:

❌ Large sized vein – Incorrect. The aorta is an artery, not a vein. Veins (like the superior vena cava) carry deoxygenated blood back to the heart and have thinner walls compared to arteries.

❌ Small artery – Incorrect. The aorta is a large artery, not a small one. Small arteries supply specific organs and tissues further down the vascular tree.

❌ Arteriole – Incorrect. Arterioles are the smallest arteries that regulate blood flow into capillary networks and help control blood pressure. The aorta is much larger than an arteriole.

❌ Medium muscular artery – Incorrect. Medium-sized arteries (muscular arteries) have more smooth muscle and fewer elastic fibers compared to the aorta. Examples include the brachial and femoral arteries.

“For heart muscle to contract in a synchronized manner, cells must ‘talk’ to each other electrically. Which junction allows ions to pass directly between adjacent cells?”

25 / 54

Tags: 2020

Which cell junction, located at intercalated disks, is responsible for electrical communication between cardiac muscle cells?

Zonula adherens

Macula adherens

Zonula occludens

Gap junction

Desmosomes

Cardiac muscle cells must work synchronously to ensure efficient contraction of the heart. This synchronization is achieved through intercalated disks, which contain specialized cell junctions that facilitate both mechanical and electrical communication.

Types of Junctions in Intercalated Disks:

Intercalated disks contain three main types of junctions:

Gap Junctions (Responsible for Electrical Communication)
- Function:
  - Gap junctions allow direct electrical communication between cardiac muscle cells.
  - They permit ion flow (e.g., Na⁺, K⁺, and Ca²⁺) between adjacent cells, which is essential for the propagation of action potentials across the heart.
- Structure:
  - Made up of connexin proteins that form connexons, creating channels between cells.
- Importance:
  - Essential for synchronous contraction of cardiac muscle (e.g., in atria and ventricles).
  - Without gap junctions, electrical impulses would not be efficiently transmitted, leading to arrhythmias.
Desmosomes (Macula Adherens) (Responsible for Mechanical Strength)
- Function:
  - Provide strong adhesion between cardiac muscle cells, preventing separation during contraction.
- Structure:
  - Composed of desmogleins and desmocollins, which connect to intermediate filaments.
- Importance:
  - Ensures cardiac muscle withstands the mechanical stress of continuous contraction.
Zonula Adherens (Fascia Adherens) (Responsible for Anchoring Actin Filaments)
- Function:
  - Connects actin filaments of adjacent cardiac cells to transmit contractile force across the myocardium.
- Structure:
  - Linked by cadherins, connecting to the actin cytoskeleton.
- Importance:
  - Maintains structural integrity of cardiac muscle during contraction.

Thus, the gap junctions within intercalated disks are responsible for electrical communication between cardiac muscle cells.

Why the Correct Answer is Right:

✔ Gap junction – Correct. These junctions allow ion flow between cardiac muscle cells, enabling synchronized contraction via electrical impulse transmission.

Why the Other Options Are Incorrect:

❌ Zonula occludens (Tight Junctions) – Incorrect. These prevent paracellular movement of substances and are more relevant in epithelial barriers (e.g., blood-brain barrier, intestinal epithelium), not electrical communication in cardiac muscle.

❌ Zonula adherens (Fascia Adherens) – Incorrect. These junctions anchor actin filaments of cardiac cells to allow contractile force transmission but do not facilitate electrical communication.

❌ Macula adherens (Desmosomes) – Incorrect. Desmosomes provide strong adhesion between cardiac cells but do not transmit electrical signals.

❌ Desmosomes – Incorrect. Though desmosomes help hold cardiac cells together, they are not responsible for electrical communication.

“Which blood vessel must withstand the highest pressure fluctuations and store energy during systole to ensure continuous blood flow during diastole?”

26 / 54

Tags: 2022

The microscopic structure of the tunica media consists of concentric layers of smooth muscle fibers with variable amounts of reticular and elastic fibers in between. Which of the following vessels contains the largest percentage of elastic fibers in their tunica media?

Jugular vein

Medium sized artery

Aorta

Inferior vena cava

Coronary artery

Understanding the Composition of the Tunica Media in Different Vessels

The tunica media is the middle layer of a blood vessel wall, primarily composed of smooth muscle cells, elastic fibers, and collagen. The proportion of elastic fibers varies depending on the type of vessel and its function.

Why Does the Aorta Have the Most Elastic Fibers?

The aorta is an elastic artery, meaning its tunica media contains the highest percentage of elastic fibers compared to any other blood vessel.
These elastic fibers allow the aorta to stretch and recoil in response to pulsatile blood flow from the heart.
This elasticity helps maintain continuous blood flow during diastole by storing energy from systolic contraction and releasing it when the heart relaxes.

Breakdown of Incorrect Options:

Jugular Vein → Incorrect
- Veins have thinner walls and do not require as many elastic fibers as arteries.
- The jugular vein primarily relies on valves and external forces (e.g., skeletal muscle contractions) to facilitate blood return to the heart, rather than elasticity.
Inferior Vena Cava (IVC) → Incorrect
- The IVC is a large vein, but veins generally contain very few elastic fibers compared to arteries.
- The IVC has a thin tunica media with more collagen fibers to provide structural support rather than elasticity.
Coronary Artery → Incorrect
- The coronary arteries are muscular arteries, meaning they have a higher proportion of smooth muscle and fewer elastic fibers compared to the aorta.
- Their primary role is to regulate blood flow through vasoconstriction and vasodilation, not to accommodate high-pressure pulsations like the aorta.
Medium-Sized Artery → Incorrect
- Medium-sized arteries (also called muscular arteries) contain some elastic fibers, but they have more smooth muscle than elastic tissue.
- These arteries distribute blood to organs and adjust blood flow through vasomotion, unlike the aorta, which must expand and recoil with each heartbeat.

Think about which component of lipoproteins is denser—proteins or lipids—and how this affects the overall density of the particle.

27 / 54

Tags: 2018

High-density lipoproteins (HDL) are denser than low-density lipoproteins (LDL) because of which of the following?

It has the lowest proportion of proteins

It has the highest proportion of phospholipids

It has the lowest proportion of lipids

It has the highest proportion of proteins

It has the highest proportion of fatty acids

Think about which layer of the heart wall is composed of muscle tissue and is directly responsible for contraction.

28 / 54

Tags: 2018

Which of the following is involved in generating the pumping force of the heart?

Papillary muscles

Endothelium

Epicardium

Myocardium

Endocardium

The myocardium is the muscular layer of the heart responsible for generating the pumping force. Here’s why:

Structure of the Myocardium:
The myocardium is composed of cardiac muscle cells (cardiomyocytes), which are specialized for contraction. These cells are interconnected by intercalated discs, allowing them to work in synchrony to pump blood efficiently.
Function of the Myocardium:
The myocardium contracts during systole (ventricular contraction) to eject blood from the heart into the systemic and pulmonary circulations. It relaxes during diastole (ventricular relaxation) to allow the heart chambers to fill with blood.
Key Role in Pumping Force:
The thickness of the myocardium varies in different chambers of the heart, with the left ventricle having the thickest myocardium due to its role in pumping blood to the entire body. This thickness directly correlates with the force of contraction.

Why the Other Options Are Incorrect:

Epicardium:
The epicardium is the outermost layer of the heart wall and is primarily composed of connective tissue and fat. It provides protection and support but does not contribute to the pumping force.
Endocardium:
The endocardium is the innermost layer of the heart wall, lining the chambers and valves. It is composed of endothelial cells and connective tissue and plays a role in maintaining smooth blood flow but does not generate force.
Papillary muscles:
The papillary muscles are small muscles located in the ventricles that anchor the chordae tendineae, which in turn attach to the atrioventricular valves (mitral and tricuspid valves). They prevent valve prolapse during ventricular contraction but do not directly generate the pumping force.
Endothelium:
The endothelium is a thin layer of cells lining the interior surface of blood vessels and the heart chambers. It regulates vascular tone, blood flow, and clotting but does not contribute to the pumping force of the heart.

💡 Which elastic layers are prominent in larger arteries but absent in small arterioles?

29 / 54

Tags: 2018

Which of the following structures will not be observed under a light microscopic examination of an arteriole?

Very thin tunica adventitia

Tunica intima with no connective tissue or smooth muscle

Endothelium

Internal and external elastic laminae

Circularly arranged layers of smooth muscle

💡 The femoral artery is responsible for distributing blood to the lower limb. Which category of arteries is responsible for distributing blood rather than just conducting it?

30 / 54

Tags: 2019

A boy fell from a bicycle and injured his thighs. His femoral artery was damaged. The femoral artery is of which type?

Large sized muscular artery

Medium sized muscular artery

Small sized muscular artery

Falls under the same classification as aorta

Elastic artery

Which layer of the heart is made up of cardiac muscle cells and generates the force needed for circulation?

31 / 54

Tags: 2019

Which of the following is involved in generating the pumping force of the heart?

Endocardium

Myocardium

Epicardium

Papillary muscles

Endothelium

“The inner lining of the heart must allow smooth blood flow and minimize friction, just like the inner surface of blood vessels.”

32 / 54

Tags: 2019

Which of the following types of epithelium lines the inner surface of the heart?

Simple squamous

Stratified cuboidal

Simple cuboidal

Stratified squamous

Specialized epitheilium

Think about which cell type is more common in small blood vessels and capillaries rather than large, high-pressure arteries.”

33 / 54

Tags: 2019

Which of these is odd about the structure of an elastic artery?

Presence of connective tissue

Presence of fenestrated elastic membrane in tunica media

Presence of tunica intima

Presence of pericytes in tunica media

Presence of an internal elastic lamina

Elastic arteries, such as the aorta and pulmonary arteries, are specialized for withstanding high-pressure blood flow. Their structure includes three primary layers:

Tunica intima – The innermost layer, consisting of an endothelium (simple squamous epithelium), a subendothelial layer, and an internal elastic lamina (IEL).
Tunica media – The thickest layer, composed of fenestrated elastic membranes (elastin sheets), smooth muscle cells, and collagen. This elastic structure allows the artery to stretch and recoil with each heartbeat.
Tunica adventitia – The outermost layer, containing connective tissue, vasa vasorum (small blood vessels that supply large arteries), and nerves.

Correct Answer: Presence of pericytes in tunica media

Pericytes are contractile cells that are typically found in capillaries and post-capillary venules, where they provide structural support and regulate permeability. They are not found in the tunica media of elastic arteries, which instead consists of smooth muscle cells and fenestrated elastic membranes.

Why the Other Options Are Correct Components of an Elastic Artery?

Presence of fenestrated elastic membrane in tunica media ✅
- Elastic arteries have multiple fenestrated elastic membranes in their tunica media. These allow for the diffusion of nutrients and oxygen to smooth muscle cells deep within the wall.
Presence of an internal elastic lamina ✅
- The internal elastic lamina (IEL) is a distinct, wavy layer of elastin that separates the tunica intima from the tunica media. It is present in all arteries but is more prominent in muscular arteries.
Presence of tunica intima ✅
- Like all blood vessels, elastic arteries have a tunica intima, which includes an endothelial layer that lines the lumen.
Presence of connective tissue ✅
- The tunica adventitia contains connective tissue (mostly collagen and elastic fibers), which provides structural support and elasticity to the artery.

“Think about the largest artery in the body, which carries oxygenated blood from the heart to the rest of the body. How is it classified based on its size and structure?”

34 / 54

Tags: 2019

The aorta is a big vessel arising from the heart. Which of the following is correct regarding the aorta?

Large sized vein

Small artery

Medium muscular artery

Arteriole

Large sized artery

“Which layer of the heart is composed of contractile cells that actively generate the force required to push blood forward?”

35 / 54

Tags: 2022

Which of the following is involved in generating the pumping force of the heart?

Endothelium

Papillary muscles

Myocardium

Endocardium

Epicardium

Think about small vessels that nourish the outer layers arteries and veins, ensuring that cells far from the lumen receive adequate oxygen and nutrients.

36 / 54

Tags: 2020

Vasa vasorum are predominantly found in large blood vessels, large arteries, and large veins. What are the vasa vasorum?

Blood vessels of the myocardium

Blood vessels of the endocardium

Blood vessels within the walls of blood vessels

Nerves of the heart

Nerves that supply the blood vessels

“Consider how cardiac muscle needs to maintain strong connections between cells for coordinated contractions. The nucleus placement should support this function while differing from other muscle types.”

37 / 54

Tags: 2016

Which of the following is true about the position of a nucleus in a cardiac muscle cell?

Single peripherally located nucleus

Multiple nuclei aggregated in the center

Multiple peripherally located nuclei

Single centrally located nucleus

It is anuclear

“Intercalated discs are found in cardiac muscle, ensuring strong cell attachment and rapid electrical conduction. However, a key structure used for anchoring filaments in smooth muscle is absent here—what could it be?”

38 / 54

Tags: 2016

Which one of the following is not present at intercalated discs?

Communicating junctions

Fascia adherens

Dense bodies

Gap junctions

Desmosomes

Intercalated discs are specialized structures found in cardiac muscle tissue, which connect individual cardiac muscle cells (cardiomyocytes) to one another. These discs play a crucial role in maintaining the structural integrity of the heart and facilitating electrical and mechanical coupling for synchronized contractions.

Intercalated discs contain three key types of cell junctions:

Gap Junctions – Allow electrical impulses to pass between cardiac cells, enabling synchronized contraction.
Desmosomes – Provide strong mechanical adhesion between cells to resist the stress of repeated contractions.
Fascia Adherentes – Anchor actin filaments of the cardiac muscle fibers to the plasma membrane, helping in force transmission during contraction.

Correct Answer (Not Present in Intercalated Discs):

✅ Dense bodies

Dense bodies are found in smooth muscle cells, not in cardiac muscle.
They function similarly to Z-discs in skeletal and cardiac muscle, serving as attachment sites for actin filaments.
Since intercalated discs are exclusive to cardiac muscle and do not contain dense bodies, this is the correct answer.

Incorrect Options:

❌ Communicating junctions

These are another name for gap junctions, which are present in intercalated discs.
They allow the passage of ions and electrical signals, ensuring rapid conduction of impulses throughout the heart.

❌ Fascia adherentes

These are specialized adherens junctions found in cardiac muscle but not in skeletal muscle.
They anchor actin filaments of the sarcomeres to the plasma membrane, allowing force transmission between cardiac cells.

❌ Gap junctions

These electrically couple cardiac muscle cells, allowing the heart to function as a syncytium (a coordinated unit).
They enable rapid ion flow (such as calcium and sodium), essential for rhythmic contractions.

❌ Desmosomes

These provide mechanical strength by linking intermediate filaments of adjacent cardiomyocytes.
Desmosomes prevent cardiac cells from pulling apart under mechanical stress.

Think about which structure belongs to smooth muscle, not cardiac muscle.

39 / 54

Tags: 2016

Which one of the following is not present at intercalated discs?

Communicating junctions

Desmosomes

Gap junctions

Fascia adherentes

Dense bodies

These capillaries have larger openings than usual, allowing not just molecules but even cells to pass through. Think of organs involved in blood filtration and cell production—this type of capillary is essential for those functions.

40 / 54

Tags: 2021

Which of the following type of vessels are present in liver, spleen and bone marrow?

Continuous capillaries

Sinusoidal capillaries

Fenestrated capillaries

Muscular arteries

Elastic arteries

he sinusoidal capillaries are specialized blood vessels found in certain organs, including the liver, spleen, and bone marrow. These capillaries are distinct from other types of capillaries due to their larger diameter and irregular shape, allowing for more efficient exchange of larger molecules and cells between the bloodstream and the tissues. Here’s a closer look:

Sinusoidal capillaries have larger pores (or gaps between endothelial cells) and a more irregular shape than other types of capillaries. These features allow for the passage of larger molecules such as proteins and even cells (e.g., red and white blood cells). This is essential for the functions of the liver (processing blood and filtering toxins), the spleen (filtering blood and removing old red blood cells), and the bone marrow (producing blood cells).
Liver: The sinusoidal capillaries in the liver allow for the exchange of proteins, nutrients, and waste products between the blood and hepatocytes (liver cells). They also facilitate the movement of blood cells during the maturation process in the bone marrow.
Spleen: Sinusoidal capillaries in the spleen allow for the filtration of blood, where old red blood cells are removed, and the recycling of iron from hemoglobin occurs.
Bone marrow: Sinusoidal capillaries are important in the bone marrow, as they allow newly formed blood cells to enter the bloodstream.

Why the Other Options Are Incorrect:

Continuous capillaries: These capillaries are the most common type and are characterized by tight junctions between endothelial cells with no gaps. They are found in muscle tissue, skin, lungs, and the central nervous system, but they are not found in the liver, spleen, or bone marrow.
Elastic arteries: These are large arteries such as the aorta and pulmonary artery that have a large amount of elastic tissue to allow for expansion and recoil. These arteries are not found in the liver, spleen, or bone marrow.
Muscular arteries: These arteries have a thicker muscle layer and are responsible for distributing blood to specific organs and tissues. They are not present in the liver, spleen, or bone marrow.
Fenestrated capillaries: These capillaries have pores (fenestrations) in the endothelial cells, which allow for greater exchange of small molecules. They are typically found in places like the kidneys, intestines, and endocrine glands, but not in the liver, spleen, or bone marrow.

Conclusion:

Sinusoidal capillaries are the specialized blood vessels present in the liver, spleen, and bone marrow, allowing for the exchange of larger molecules and cells.

Correct Answer: Sinusoidal capillaries

“Think about the type of artery that regulates blood flow to specific organs and tissues. Which artery has a well-defined internal elastic lamina to withstand high pressure?”

41 / 54

Tags: 2019

In some arteries, the tunica intima is separated from the tunica media by a fenestrated sheet of an elastic material called the internal elastic lamina. This material is most clearly seen in which of the following?

Inferior vena cava

Muscular arteries

Arterioles

Aorta

Medium sized vein

This layer consists of cardiac muscle fibers, which generate the force necessary for ventricular contraction, ensuring effective blood circulation.

42 / 54

Tags: 2021

A patient presents to the outpatient department and is diagnosed with peripheral insufficiency due to decreased contractility of the heart. Which layer of the heart is responsible for contractility?

Pericardium

Epicardium

Endocardium

Myocardium

Sub-epicardium

These structures are composed of elastin, arranged in concentric layers, and are crucial for maintaining arterial elasticity. They adapt over time due to hemodynamic stress and aging.

43 / 54

Tags: 2021

Which of the following statements is true regarding the fenestrated elastic membranes present in the elastic arteries?

They range in size from 60 nm to 70 nm

They will be different in different arteries

They will be different in different regions of body

They will be different in males and females

Their size range will increase will age

“Think about the smallest blood vessels in the body, where exchange of nutrients and gases occurs. Which type of vessel is closely associated with pericytes?”

44 / 54

Tags: 2021

Which of the following types of vessels are lined with pericytes?

Veins

Capillaries

Venules

Arterioles

Arteries

This type of epithelium is found lining the inner surface of blood vessels and the heart, allowing for smooth blood flow and minimal resistance.

45 / 54

Tags: 2021

Endocardium consists of which type of epithelium?

Stratified squamous keratinized

Simple columnar

Simple cuboidal

Stratified squamous non-keratinized

Simple squamous

Think about the type of epithelium that lines blood vessels. The inner heart surface is a continuation of this same structure.

46 / 54

Tags: 2018

Which of the following types of epithelium lines the inner surface of the heart?

Stratified cuboidal

Specialized epitheilium

Simple cuboidal

Stratified squamous

Simple squamous

Think about the type of tissue that provides structural support beneath the endothelium while maintaining flexibility and smoothness inside the heart chambers.

47 / 54

Tags: 2018

The endocardium consists of endothelium and what other tissue?

Fibrous tissue

Thin connective tissue

Only endothelium

Muscular tissue

Nervous tissue

Think about how large arteries receive their own blood supply. Would the vasa vasorum be located in an area where diffusion from the lumen is sufficient?

48 / 54

Tags: 2018

Which of the following is incorrect regarding elastic arteries?

Tunica media consists of smooth muscle

None of the options

They have elastic lamallae in tunica media

They are present close to the heart

Their vaso vasorum is in the inner wall of the vessel

Consider how pericytes interact with the structure of blood vessels. If they help regulate capillary function, think about whether they would need a direct physical connection to endothelial cells.

49 / 54

Tags: 2018

Pericytes are cells with muscular content. Which of the following is incorrect regarding them?

Their processes extend around vessel

They help to regulate blood flow to tissue by relaxing and contracting

Endothelial cell and pericytes do not share a common basement membrane

They are contractile

They surround capillaries and vessels

Think about arteries that need to withstand the high pressure from the heart and must expand and recoil with each heartbeat. These vessels are closest to the heart and contain many layers of elastic fibers.

50 / 54

Tags: 2018

A student is studying a histological slide showing cross-section of a vessel and he sees many elastic lamellar layers. Which of the following is shown in the slide?

Medium Veins

Elastic artery

Large veins

Arterioles

MuscuIar artery

These structures are crucial for ensuring blood flows in one direction, especially in veins with numerous valves. In some veins, the valves play a more visible and important role in maintaining circulation.

51 / 54

Tags: 2021

Which of the following statements is inappropriate regarding the valves in the veins?

Usually in paired structures

Lined with endothelium

Formed from the folds of tunica intima

Inconspicuous in veins that transport blood against the force of gravity

Able to prevent the backflow of blood

Question Breakdown:

The question asks which of the following statements is inappropriate regarding the valves in the veins. To answer this, we need to understand the function, structure, and location of venous valves.

Key Concepts to Understand:

Valves in Veins: Venous valves are one-way valves that are found predominantly in the lower extremities and upper limbs, where they prevent the backflow of blood and help return blood to the heart, especially against the force of gravity.
Structure of Valves: Venous valves are formed from folds of the tunica intima, the innermost layer of the blood vessel, and they are lined with endothelium (the same tissue that lines the entire vascular system).

Answer Breakdown:

Correct Answer: Inconspicuous in veins that transport blood against the force of gravity

Inconspicuous in veins that transport blood against the force of gravity: This statement is inappropriate because valves in veins are actually more prominent and important in veins that are transporting blood against gravity, such as in the legs. These veins require strong valves to prevent the blood from flowing backward due to gravity. Therefore, the valves are not inconspicuous in veins that carry blood upward (e.g., in the legs) but are essential for their function.
Why it’s incorrect: Veins in the legs and other parts of the body that work against gravity have a higher number of valves to ensure proper blood flow towards the heart. Valves are not inconspicuous in these veins but are necessary to avoid venous reflux (backflow of blood), which could otherwise lead to conditions like varicose veins.

Why the Other Options Are Correct:

1. Usually in paired structures

Venous valves are often found in pairs. Each valve consists of two flaps or cusps that function together to prevent backflow.
Why it’s correct: Venous valves are typically paired, with one cusp facing toward the heart and the other preventing backward flow.

2. Able to prevent the backflow of blood

The primary function of venous valves is to prevent the backflow of blood. They ensure that blood moves in one direction towards the heart and prevent the gravitational pull from reversing the blood flow.
Why it’s correct: This is one of the fundamental functions of venous valves.

3. Lined with endothelium

Venous valves are lined with endothelium, the same tissue that lines the inner surface of all blood vessels. This is part of their structure.
Why it’s correct: The endothelium is the inner lining of blood vessels, and the valve cusps are an extension of this lining.

4. Formed from the folds of tunica intima

Venous valves are formed from folds of the tunica intima, the innermost layer of the blood vessel. These folds project into the lumen of the vein, creating the one-way valve mechanism.
Why it’s correct: The valves are formed from the tunica intima (inner layer) and are a continuation of the endothelial lining.

Conclusion:

The statement that “valves in veins are inconspicuous in veins that transport blood against the force of gravity” is inappropriate because valves are more prominent in veins that are working against gravity, especially in the lower limbs, where they prevent the backflow of blood.

Correct Answer: Inconspicuous in veins that transport blood against the force of gravity

These cells are the workhorses of the heart, responsible for its rhythmic contraction. They have a striated appearance and are interconnected by intercalated discs to allow synchronized contraction. Think about the muscle cells that enable the heart to pump blood efficiently.

52 / 54

Tags: 2021

The histological section of the heart myocardium shows which of the following cell types?

Myocardial endocrine cells

Endothelial cells

Purkinje myocytes

Stem cells

Cardiac myocytes

Question Breakdown:

The question is asking about the cell types found in a histological section of the heart myocardium. The myocardium is the thick muscular layer of the heart, responsible for contraction and pumping blood. Understanding the structure and function of the myocardium is key to answering this question.

Key Concepts to Understand:

Heart Myocardium: The myocardium is the muscular middle layer of the heart wall. It is composed mainly of cardiac myocytes (heart muscle cells) that contract to pump blood throughout the body.
Histological Section: A histological section refers to a thin slice of tissue prepared for microscopic examination, allowing us to observe the different cell types and structures present in the tissue.

Answer Breakdown:

Correct Answer: Cardiac Myocytes

Cardiac Myocytes (Heart Muscle Cells): These are the contractile cells of the heart, responsible for the pumping action. Cardiac myocytes are striated and interconnected by intercalated discs, which allow the heart muscle to contract in a coordinated manner.
- Why it’s correct: The myocardium is primarily composed of cardiac myocytes, which are specialized for contraction. These cells are abundant in the heart and form the bulk of the myocardium.

Why the Other Options Are Incorrect:

1. Stem Cells

Stem Cells are undifferentiated cells with the ability to differentiate into various cell types. While there are cardiac stem cells in the heart that contribute to tissue repair, they are not the predominant cell type in the myocardium.
Why it’s incorrect: Stem cells are not the primary cell type in the heart myocardium. Instead, cardiac myocytes make up most of the myocardial tissue.

2. Purkinje Myocytes

Purkinje Fibers are specialized modified cardiac muscle cells that are part of the conduction system of the heart. They help conduct electrical impulses to ensure coordinated heart contractions.
- Why it’s incorrect: Purkinje fibers are present in the heart, but they are not the main component of the myocardium. They are found in the inner part of the myocardium, especially near the ventricles, and are involved in conduction, not contraction.

3. Endothelial Cells

Endothelial Cells line the blood vessels and form a barrier between the blood and the tissues. They are found in the inner lining of blood vessels, not in the myocardium itself.
Why it’s incorrect: Endothelial cells are part of the blood vessel walls (arteries, veins, capillaries) and not the heart muscle. The myocardium consists mainly of cardiac myocytes, not endothelial cells.

4. Myocardial Endocrine Cells

Myocardial Endocrine Cells are specialized cells in the heart that can secrete hormones, such as atrial natriuretic peptide (ANP), but these cells are relatively few in number compared to cardiac myocytes.
Why it’s incorrect: While endocrine cells in the heart play a role in hormone secretion, they are not the predominant cell type in the myocardium. The myocardium is primarily composed of cardiac myocytes.

Conclusion:

The histological section of the heart myocardium will primarily show cardiac myocytes as the predominant cell type, responsible for the contraction of the heart. While other cell types, like Purkinje fibers and endothelial cells, are present in specific areas, cardiac myocytes are the most abundant in the myocardium.

“These specialized cells in the thymus help shape and educate T cells by presenting self-molecules and supporting their development.”

53 / 54

Tags: 2016

Proper maturation of pre-T cells involves interaction with which of the following?

Hassall's corpuscles

Plasma cells

Circulating antigen

Reticular cells and fibers

Epithelial reticular cells

The proper maturation of pre-T cells occurs in the thymus, where immature T lymphocytes (thymocytes) undergo selection and differentiation into functional T cells. This process is critically dependent on epithelial reticular cells (ERCs) in the thymic cortex and medulla.

Role of Epithelial Reticular Cells (ERCs) in T-Cell Maturation:

Structural Support:
- ERCs form a three-dimensional framework in the thymic cortex and medulla, guiding the development of pre-T cells.
Positive Selection (Cortex):
- ERCs in the cortex express self-MHC molecules, which interact with immature T cells.
- Only T cells that can recognize self-MHC molecules survive (positive selection), while those that do not undergo apoptosis.
Negative Selection (Medulla):
- ERCs in the medulla help eliminate T cells that strongly bind to self-antigens, preventing autoimmune reactions.
- This process ensures that only self-tolerant T cells enter circulation.
Secretion of Cytokines and Hormones:
- ERCs produce thymic hormones like thymosin, thymopoietin, and IL-7, which support T-cell differentiation.

Thus, epithelial reticular cells are essential for guiding pre-T cells through the processes of selection and maturation in the thymus.

Why the Other Options Are Incorrect:

Reticular cells and fibers (Incorrect)
- Reticular cells produce reticular fibers (type III collagen) and form a supportive meshwork in secondary lymphoid organs (e.g., lymph nodes, spleen, and bone marrow).
- However, the thymus lacks reticular fibers, and instead, epithelial reticular cells form the supportive framework.
Plasma cells (Incorrect)
- Plasma cells are fully differentiated B cells that secrete antibodies.
- They are not involved in T-cell maturation, which occurs independently in the thymus.
Circulating antigen (Incorrect)
- Developing T cells in the thymus do not encounter circulating antigens.
- Instead, they undergo selection based on self-MHC molecules and self-antigens presented by ERCs.
- Antigen exposure occurs after T cells leave the thymus and enter secondary lymphoid organs.
Hassall’s corpuscles (Incorrect)
- Hassall’s corpuscles are whorled structures found in the thymic medulla, composed of degenerating epithelial reticular cells.
- While they may play a role in regulating immune tolerance, they are not directly involved in the maturation of pre-T cells.

Think about arteries that require both elasticity and the ability to regulate blood flow. These vessels are the main distribution channels to organs and have a distinct internal elastic lamina.

54 / 54

Tags: 2018

In some arteries, the tunica intima is separated from the tunica media by a fenestrated sheet of an elastic material called the internal elastic lamina. This material is most clearly seen in which of the following?

Medium sized vein

Inferior vena cava

Aorta

Muscular arteries

Arterioles

Your score is

The average score is 0%

0%

Thank you for your feedback.

CVS – HISTO

Report a question

❌ Why the other options are incorrect

❌ Why the other options are incorrect

❌ Why the other options are incorrect

Key Features of Lymphatic Capillaries:

Why “Present in bone marrow” is the odd one out?

Analysis of Each Option:

Key Features of the Endocardium:

Analysis of Each Option:

Analysis of Each Option:

Why the Other Options Are Incorrect:

Types of Capillaries and Their Characteristics:

Why “Elastin” is the Correct Answer:

Why the Other Options Are Incorrect:

✅ Correct Answer: “Presence of pericytes in tunica media”

Why the Other Options are Correct:

✅ Correct Answer: “Not present in visceral veins”

Why the Other Options are Correct:

Analysis of the Incorrect Options

Analysis of the Incorrect Options

Analysis of the Incorrect Options

Analysis of the Incorrect Options

Analysis of the Incorrect Options

Analysis of the Incorrect Options

Analysis of the Incorrect Options

Why the Other Options Are Correct:

Key Features of the Aorta:

Why the Correct Answer is Right:

Why the Other Options Are Incorrect:

Types of Junctions in Intercalated Disks:

Why the Correct Answer is Right:

Why the Other Options Are Incorrect:

Understanding the Composition of the Tunica Media in Different Vessels

Why Does the Aorta Have the Most Elastic Fibers?

Breakdown of Incorrect Options:

Why This is Correct:

Why the Other Options Are Incorrect:

Why the Other Options Are Incorrect:

Histological Structure of Arterioles:

Key Feature That Will Not Be Observed:

Correct Answer:

Why the Other Options Are Incorrect:

Correct Answer:

Why the Other Options Are Incorrect:

Correct Answer:

Why the Other Options Are Incorrect:

Why the Other Options Are Incorrect?

Correct Answer: Presence of pericytes in tunica media

Why the Other Options Are Correct Components of an Elastic Artery?

Why the Other Options Are Incorrect:

Understanding the Myocardium’s Role in Pumping the Heart

Why is the Myocardium Responsible for Pumping Force?

Breakdown of Incorrect Options:

Where Are They Found?

Why the Other Options Are Incorrect?

✅ Correct Answer:

❌ Incorrect Options:

Correct Answer (Not Present in Intercalated Discs):

Incorrect Options:

❌ Why the other options are incorrect:

Why the Other Options Are Incorrect:

Conclusion:

Correct Answer: Sinusoidal capillaries

Why the Other Options Are Incorrect:

Why Are the Other Options Incorrect?

1. Endocardium (Incorrect)

2. Sub-Epicardium (Incorrect)

3. Epicardium (Incorrect)

4. Pericardium (Incorrect)

Why Are the Other Options Incorrect?

1. They will be different in males and females (Incorrect)

2. They range in size from 60 nm to 70 nm (Incorrect)

3. They will be different in different arteries (Incorrect)

4. They will be different in different regions of the body (Incorrect)

Why the Other Options Are Incorrect:

Why Are the Other Options Incorrect?

1. Simple Cuboidal (Incorrect)

2. Stratified Squamous Non-Keratinized (Incorrect)

3. Stratified Squamous Keratinized (Incorrect)